The relationship between plasma GIP and GLP-1 levels in individuals with normal and impaired glucose tolerance.
Date
2020
Authors
Marathe, C.S.
Pham, H.
Marathe, J.A.
Trahair, L.G.
Huynh, L.
Wu, T.
Phillips, L.K.
Rayner, C.K.
Nauck, M.A.
Horowitz, M.
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Journal article
Citation
Acta Diabetologica, 2020; 57(5):583-587
Statement of Responsibility
Chinmay S. Marathe, Hung Pham, Jessica A. Marathe, Laurence G. Trahair, Lian Huynh, Tongzhi Wu, Liza K. Phillips, Christopher K. Rayner, Michael A. Nauck, Michael Horowitz, Karen L. Jones
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Abstract
Aims Glucose-dependent insulinotropic polypeptide (GIP) is released primarily from the proximal small intestine and glucagon-like peptide-1 (GLP-1) from the more distal small intestine and colon. Their relative importance to the incretin effect in health has been contentious in the past, although it now appears that GIP has the dominant role. It is uncertain whether there is a relationship between GIP and GLP-1 secretion. We aimed to evaluate the relationship between plasma GIP and GLP-1 responses to a 75-g oral glucose load in individuals with normal (NGT) and impaired glucose tolerance (IGT). Methods One hundred healthy subjects had measurements of blood glucose, serum insulin, plasma GIP and GLP-1 concentrations for 240 min after a 300 mL drink containing 75 g glucose. Results Fifty had NGT and 41 IGT; 9 had type 2 diabetes and were excluded from analysis. In both groups, there were increases in plasma GIP and GLP-1 following the glucose drink, with no difference in the magnitude of the responses between t = 0–240 min. There was a weak relationship between the iAUC 0–240 min for GIP and GLP-1 in the combined (r = 0.23, P = 0.015) and in the IGT (r = 0.34, P = 0.01), but not in the NGT (r = 0.15, P = 0.14) group. Conclusions There is a weak relationship between oral glucose-induced GIP and GLP-1 secretions in non-diabetic subjects.
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© Springer-Verlag Italia S.r.l., part of Springer Nature 2019