Changes in antibiotic distribution due to pancreatitis
Date
2011
Authors
Fanning, K.J.
Robertson, T.A.
Prins, J.B.
Roberts, M.S.
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Journal article
Citation
Antimicrobial Agents and Chemotherapy, 2011; 55(6):3008-3011
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Abstract
This work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control animals and animals with pancreatitis. Meropenem and piperacillin distributed into the extracellular space, and their distribution kinetics were unaffected by pancreatitis. In contrast, in pancreatic cells from animals with pancreatitis, ciprofloxacin showed a reduced uptake and clindamycin showed a reduced distribution.
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Copyright 2011 American Society for Microbiology