Mechanistic insight into loading of doxorubicin hydrochloride onto carbonized FeNPs@ZIF-8 composite
Date
2023
Authors
Cai, W.
Ye, Y.
Weng, X.
Owens, G.
Chen, Z.
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Separation and Purification Technology, 2023; 314:1-11
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Abstract
The increasing global efflux of antibiotics into aquatic environments has significant detrimental impacts on natural ecosystems. Consequently, the controlled release of antibiotics and their metabolites is an important issue. In this paper, a new carbonized iron nanoparticles-metal organic framework (C-Fe₃O₄@ZIF-8) composite was used to load doxorubicin hydrochloride (DOX), where loading efficiencies of 75.2, 62.1, 48.4 and 20.5% were observed when using C-Fe₃O₄@ZIF-8, C-ZIF-8, Fe@ZIF-8 and Fe₃O₄, respectively. A DOX loading efficiency of 94.7% was reached under optimized conditions. Analysis of the UV–Visible spectra of DOX showed that no significant degradation products were evident, indicating that loading of DOX on C-Fe₃O₄@ZIF-8 was via adsorption.
FTIR and XPS analysis together with pH dependant changes in adsorption suggested that C-Fe₃O₄@ZIF-8 adsorbed DOX through a combination of surface complexation and electrostatic interaction. Furthermore, isothermal adsorption studies revealed that the adsorption of DOX on C-Fe₃O₄@ZIF-8 followed the Langmuir model, and the pseudo-second-order kinetic model, indicating that adsorption was dominated by chemisorption, and thus the loading mechanism was proposed based on specific site adsorption. Finally, the magnetic property of C-Fe₃O₄@ZIF-8 was relativity easy to separate, and accordingly have desirable recycle/reuse performance.
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Copyright 2023 Elsevier B.V.