Establishing the role of pre-implantation genetic diagnosis with human leucocyte antigen typing: what place do "saviour siblings" have in paediatric transplantation?

Simple item page
dc.contributor.authorSamuel, G.
dc.contributor.authorStrong, K.
dc.contributor.authorKerridge, I.
dc.contributor.authorJordens, C.
dc.contributor.authorAnkeny, R.
dc.contributor.authorShaw, P.
dc.date.issued2009
dc.description.abstractBackground: Not all children in need of a haematopoietic stem cell transplant have a suitable relative or unrelated donor available. Recently, in vitro fertilisation (IVF) with pre-implantation genetic diagnosis (PGD) for human leucocyte antigen (HLA) tissue typing has been used to selectively transfer an IVF embryo in order to produce a child who may provide umbilical cord blood for transplantation to an ill sibling. Such children are sometimes called “saviour siblings”. Objective: To examine the published clinical and epidemiological evidence relevant to the use of this technology, with the aim of clarifying those situations where IVF and PGD for HLA typing should be discussed with parents of an ill child. Design: A critical analysis of published literature on comparative studies of umbilical cord blood versus other sources of stem cells for transplantation; comparative studies of matched unrelated donor versus matched related donor transplantation; and the likelihood of finding an unrelated stem cell donor. Conclusion: IVF and PGD for HLA typing is only applicable when transplantation is non-urgent and parents are of reproductive age. Discussions regarding this technology may be appropriate where no suitable related or unrelated donor is available for a child requiring a transplant, or where no suitable related donor is available and transplantation is only likely to be entertained with a matched sibling donor. Discussion may also be considered in the management of any child lacking a matched related donor who requires a non-urgent transplant or may require a transplant in the future.
dc.description.statementofresponsibilityG N Samuel, K A Strong, I Kerridge, C F C Jordens, R A Ankeny, P J Shaw
dc.identifier.citationArchives of Disease in Childhood, 2009; 94(4):317-320
dc.identifier.doi10.1136/adc.2008.138529
dc.identifier.issn0003-9888
dc.identifier.issn1468-2044
dc.identifier.orcidAnkeny, R. [0000-0002-1547-6031]
dc.identifier.urihttp://hdl.handle.net/2440/50855
dc.language.isoen
dc.provenancePublished Online First: 6 August 2008
dc.publisherBritish Med Journal Publ Group
dc.rightsCopyright © 2009 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
dc.source.urihttps://doi.org/10.1136/adc.2008.138529
dc.subjectFetal Blood
dc.subjectHumans
dc.subjectHLA Antigens
dc.subjectPreimplantation Diagnosis
dc.subjectFertilization in Vitro
dc.subjectDonor Selection
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectParents
dc.subjectSiblings
dc.subjectPediatrics
dc.subjectPregnancy
dc.subjectEthics, Medical
dc.subjectChild
dc.subjectFemale
dc.titleEstablishing the role of pre-implantation genetic diagnosis with human leucocyte antigen typing: what place do "saviour siblings" have in paediatric transplantation?
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

History publications