A critical evaluation of probes for cysteine sulfenic acid
Date
2021
Authors
Pople, J.M.M.
Chalker, J.M.
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Journal article
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Current Opinion in Chemical Biology, 2021; 60:55-65
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Abstract
Cysteine oxidation is important in cellular redox regulation, signaling, and biocatalysis. To understand the biological relevance of cysteine oxidation, it is desirable to identify the proteins involved, the site of the oxidized cysteine, and the relevant oxidation states. Because the thiol of cysteine can be converted to a wide range of oxidation states, mapping these oxidative modifications is challenging. The dynamic and reversible nature of many cysteine oxidation states compounds the difficulty in such proteomic analyses. In this review, we examine methods to detect cysteine sulfenic acid — a particularly challenging functional group to analyze because of its reactive nature. We focus on the selectivity of recently reported probes and discuss some challenges and opportunities in this field.
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Copyright 2020 Elsevier