Embryo culture and long-term consequences

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dc.contributor.authorThompson, J.
dc.contributor.authorMitchell, M.
dc.contributor.authorKind, K.
dc.date.issued2007
dc.descriptionCopyright © 2007 IETS
dc.description.abstractThe development of pre-elongation (ruminants) and preimplantation (e.g. mouse and humans) embryos ex vivo has evolved over the past four decades into a reliable technology that is used as a research tool in developmental biology, as well as other embryo technologies, for application in infertility treatment, species conservation and selective breeding. It is clear from a variety of embryo culture studies that adaptive responses by embryos during culture can lead to significant alterations in subsequent developmental profiles, the mechanisms of which are not entirely clear but are unlikely to be limited to a single mechanism because this does not account for the variability seen in responses and the emerging list of specific cellular stressors that cause long-term deviations in fetal development. Epigenetic mechanisms, especially deviation of methylation patterns, and adaptation via causal pathways linking gene expression signalling with critical developmental time points, especially of placental development, are two candidates. Observational studies on post-transfer consequences must now be designed so that specific candidate pathways are followed to elucidate their role in perturbed development following transfer.
dc.description.statementofresponsibilityJeremy G. Thompson, Megan Mitchell and Karen L. Kind
dc.identifier.citationReproduction, Fertility and Development, 2007; 19(1):43-52
dc.identifier.doi10.1071/RD06129
dc.identifier.issn1031-3613
dc.identifier.issn1448-5990
dc.identifier.orcidThompson, J. [0000-0003-4941-7731]
dc.identifier.orcidMitchell, M. [0000-0002-4284-2201]
dc.identifier.urihttp://hdl.handle.net/2440/43004
dc.language.isoen
dc.publisherC S I R O Publishing
dc.source.urihttp://www.publish.csiro.au/?act=view_file&file_id=RD06129.pdf
dc.subjectPlacenta
dc.subjectAnimals
dc.subjectCattle
dc.subjectHumans
dc.subjectMice
dc.subjectCulture Media
dc.subjectEmbryo Transfer
dc.subjectCoculture Techniques
dc.subjectEmbryo Culture Techniques
dc.subjectAdaptation, Physiological
dc.subjectEpigenesis, Genetic
dc.subjectEmbryonic Development
dc.subjectFetal Development
dc.subjectPregnancy
dc.subjectQuaternary Ammonium Compounds
dc.subjectFemale
dc.titleEmbryo culture and long-term consequences
dc.typeJournal article
pubs.publication-statusPublished

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