Birth outcomes in women with gestational diabetes managed by lifestyle modification alone: The PANDORA Study

Date

2019

Authors

Cheng, E.
Longmore, D.
Barzi, F.
Barr, E.L.M.
Lee, I.
Whitbread, C.
Boyle, J.A.
Oats, J.
Connors, C.
McIntyre, H.D.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

Diabetes Research and Clinical Practice, 2019; 157:107876-1-107876-10

Statement of Responsibility

E. Cheng, D.K. Longmore, F. Barzi, E.L.M. Barr, I.L. Lee, C. Whitbread, J.A. Boyle, J. Oats, C. Connors, H.D. McIntyre, M. Kirkwood, K. Dempsey, X. Zhang, S. Thomas, D. Williams, P. Zimmet, A.D.H. Brown, J.E. Shaw, L.J. Maple-Brown [On behalf of PANDORA Study Research Team]

Conference Name

DOI

10.1016/j.diabres.2019.107876

Abstract

Aims: To assess outcomes of women in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort with gestational diabetes mellitus (GDM) managed by lifestyle modification compared with women without hyperglycaemia in pregnancy. Methods: Indigenous (n=97) and Europid (n=113) women managed by lifestyle modification were compared to women without hyperglycaemia (n=235). Multivariate linear and logistic regressions assessed whether GDM-lifestyle women had poorer outcomes compared to women without hyperglycaemia. Results: Women with GDM-lifestyle had higher body mass index and lower gestational weight gain than women without hyperglycaemia. On univariate analysis, gestational age at delivery was lower and induction rates were higher in women with GDM-lifestyle than without hyperglycaemia. On multivariable regression, GDM-lifestyle was associated with lower gestational age at delivery (by 0.73 weeks), lower birthweight z-score (by 0.26, p=0.007), lower likelihood of large for gestational age (LGA) [OR (95% CI): 0.55 (0.28, 1.02), p=0.059], and greater likelihood of labour induction [2.34 (1.49, 3.66), p < 0.001] than women without hyperglycaemia Conclusion: Women with GDM managed by lifestyle modification had higher induction rates and their offspring had lower birthweight z-scores, with a trend to lower LGA than those without hyperglycaemia in pregnancy. Further studies are indicated to explore reasons for higher induction rates.

School/Discipline

Dissertation Note

Provenance

Description

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Rights

© 2019 Elsevier B.V. All rights reserved.

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Grant ID

http://purl.org/au-research/grants/nhmrc/1032116
 http://purl.org/au-research/grants/nhmrc/1078333
 http://purl.org/au-research/grants/nhmrc/1038372
 http://purl.org/au-research/grants/nhmrc/1137563
 http://purl.org/au-research/grants/nhmrc/1079438
 http://purl.org/au-research/grants/nhmrc/605837
 http://purl.org/au-research/grants/nhmrc/1078477

Published Version

https://doi.org/10.1016/j.diabres.2019.107876

Call number

Persistent link to this record

http://hdl.handle.net/2440/122764