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Relationship between postprandial satiation and antral area in normal subjects

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dc.contributor.authorJones, K.
dc.contributor.authorDoran, S.
dc.contributor.authorHveem, K.
dc.contributor.authorBartholomeusz, F.
dc.contributor.authorMorley, J.
dc.contributor.authorSun, W.M.
dc.contributor.authorChatterton, B.
dc.contributor.authorHorowitz, M.
dc.date.issued1997
dc.description.abstractThe factors influencing appetite in humans are poorly understood. There is a weak relation between appetite and gastric emptying in normal subjects. Recent studies have shown that fasting and postprandial antral areas increase in patients with functional dyspepsia compared with normal subjects. We evaluated the hypothesis that antral area, and hence antral distention, is a significant determinant of postprandial fullness. Fourteen normal subjects had simultaneous measurements of gastric emptying by scintigraphy and antral area by ultrasound after ingestion of 350 mL 20% glucose. Fullness and hunger were assessed by visual analog scales. Measurements of the gastric-emptying half time (t1/2) by scintigraphy and ultrasound were not significantly different (129.6 +/- 11.8 min compared with 115.6 +/- 11.4 min). Fullness increased (P < 0.001) and hunger decreased (P < 0.001) after the drink. Both fullness and the magnitude of the increase in fullness after the drink were related to antral area (r > 0.56, P < 0.05), the increase in antral area (r > 0.59, P < 0.05), and the scintigraphic content of the distal stomach (r > 0.57, P < 0.05), but not to the ultrasound or scintigraphic t1/2 values. In contrast, hunger and the magnitude of the decrease in hunger after the drink were not related to either antral area, the increase in antral area, or the rate of gastric emptying. We conclude that postprandial fullness, but not hunger, was closely related to antral distention in normal subjects.
dc.description.statementofresponsibilityK L Jones, S M Doran, K Hveem, F D Bartholomeusz, J E Morley, W M Sun, B E Chatterton, and M Horowitz
dc.identifier.citationAmerican Journal of Clinical Nutrition, 1997; 66(1):127-132
dc.identifier.doi10.1093/ajcn/66.1.127
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.orcidMorley, J. [0000-0001-6444-2965]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.urihttp://hdl.handle.net/2440/8558
dc.language.isoen
dc.publisherAMER SOC NUTRITION-ASN
dc.rights© 1997 by The American Society for Clinical Nutrition, Inc
dc.source.urihttps://doi.org/10.1093/ajcn/66.1.127
dc.subjectPyloric Antrum
dc.subjectHumans
dc.subjectRadionuclide Imaging
dc.subjectUltrasonography
dc.subjectHunger
dc.subjectAppetite
dc.subjectGastric Emptying
dc.subjectPostprandial Period
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.titleRelationship between postprandial satiation and antral area in normal subjects
dc.typeJournal article
pubs.publication-statusPublished

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