Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
Date
2009
Authors
Benyamin, B.
Ferreira, M.A.R.
Willemsen, G.
Gordon, S.
Middelberg, R.P.S.
McEvoy, B.P.
Hottenga, J.J.
Henders, A.K.
Campbell, M.J.
Wallace, L.
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Journal article
Citation
Nature Genetics, 2009; 41(11):1173-1175
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Abstract
We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.
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Data source: Supplementary information, https://media-nature-com.access.library.unisa.edu.au/original/nature-assets/ng/journal/v41/n11/extref/ng.456-S1.pdf
Link to a related website: http://www.tweelingenregister.org/nederlands/verslaggeving/NTR-publicaties_2009/Benyamin_NG_2009.pdf, Open Access via Unpaywall
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Copyright 2009 Nature America