In vivo activity of benzoyl ester clerodane diterpenoid derivatives from Dodonaea polyandra
Date
2011
Authors
Simpson, B.
Claudie, D.
Gerber, J.
Pyke, S.
Wang, J.
McKinnon, R.
Semple, S.
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Journal article
Citation
Journal of Natural Products, 2011; 74(4):650-657
Statement of Responsibility
Bradley S. Simpson, David J. Claudie, Jacobus P. Gerber, Simon M. Pyke, Jiping Wang, Ross A. McKinnon and Susan J. Semple
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Abstract
Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α-(benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16),14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda-3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3,13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (~45% inhibition) was maintained at nanomole/ear doses.
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Copyright © 2011 The American Chemical Society and American Society of Pharmacognosy