Evaluation of the Hypoglycemic Potential of Leaves Extract of Spondias pinnata (L.f.) Kurz. From Nepal

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dc.contributor.authorSai, K.
dc.contributor.authorChhetri, S.B.B.
dc.contributor.authorDevkota, S.R.
dc.contributor.authorKhatri, D.
dc.contributor.editorCheng, J.T.
dc.date.issued2021
dc.description.abstractSpondias pinnata (L.f.) Kurz. (family: Anacardiaceae) is a wild deciduous tree indigenous to southeast Asian countries. Di0erent parts of this plant are used traditionally for the treatment and cure of various disorders and illnesses. S. pinnata leaves are used to prevent and treat diabetes in traditional Balinese medicine. However, scienti3c study on the antihyperglycemic e0ect of its leaves has not been reported yet. 'erefore, this study aims to perform phytochemical screening and investigate the hypoglycemic potential of S. pinnata leaves extract. Preliminary phytochemical screening of the hydroethanolic extract was performed following the standard tests. In vivo hypoglycemic activity of the leaves extract was evaluated using normal and glucose-loaded rats. 'e results displayed the presence of phytochemical constituents such as saponins, phenolic compounds, 7avonoids, and terpenoids. S. pinnata (500 mg/kg) and metformin (100 mg/kg) exhibited a signi3cant (p < 0.05) decrease in blood glucose level at 1, 2, and 3 h in normal rats when compared to the control group. Metformin- (100 mg/kg)- and S. pinnata- (500 mg/kg)- treated groups showed a maximum decrease in the blood glucose level at 3 h after single-dose administration in the oral glucose tolerance test (OGTT). In conclusion, S. pinnata leaves possess a signi3cant hypoglycemic activity in the animal model and thus support its traditional use to treat diabetes. 'erefore, a detailed mechanism-based study and isolation of bioactive compounds from S. pinnata leaves would be bene3cial in the future for the search of new hypoglycemic agents.
dc.description.statementofresponsibilityKusum Sai, Sumit Bahadur Baruwal Chhetri, Shankar Raj Devkota, and Deepa Khatri
dc.identifier.citationThe Scientific World Journal, 2021; 2021:3230351-1-3230351-6
dc.identifier.doi10.1155/2021/3230351
dc.identifier.issn2356-6140
dc.identifier.issn1537-744X
dc.identifier.orcidDevkota, S.R. [0000-0002-3154-7928]
dc.identifier.urihttps://hdl.handle.net/2440/146231
dc.language.isoen
dc.publisherHindawi Limited
dc.rights© 2021 Kusum Sai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1155/2021/3230351
dc.subjectAnacardiaceae; Blood Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Medicine, East Asian Traditional; Metformin; Nepal; Plant Extracts; Plant Leaves; Spondias pinnata (L.f.) Kurz
dc.subject.meshAnimals
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshAnacardiaceae
dc.subject.meshPlant Leaves
dc.subject.meshMetformin
dc.subject.meshBlood Glucose
dc.subject.meshPlant Extracts
dc.subject.meshHypoglycemic Agents
dc.subject.meshGlucose Tolerance Test
dc.subject.meshNepal
dc.subject.meshMale
dc.subject.meshMedicine, East Asian Traditional
dc.titleEvaluation of the Hypoglycemic Potential of Leaves Extract of Spondias pinnata (L.f.) Kurz. From Nepal
dc.typeJournal article
pubs.publication-statusPublished

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