Method of purifying RNA binding protein-RNA complexes
Files
(Restricted Access)
Date
2005
Authors
Darnell, R.
Jensen, K.
Ule, J.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Patent
Citation
Statement of Responsibility
Inventors: Darnell Robert, Jensen Kirk, Ule Jernej; Assignee: Darnell Robert, Jensen Kirk, Ule Jernej; Agents: Eitan, Pearl, Latzer & Cohen Zedek LLP
Conference Name
Abstract
The present invention provides methods for purifying RNA molecules interacting with an RNA binding protein (RBP), and the use of such methods to analyze a gene expression profile of a cell. The invention also provides sequences of RNA molecules that mediate binding to an RBP, proteins encoded by the sequences, a method of identifying the sequences, and the use of the sequences in a screen to identify bioactive molecules. The invention also provides RNA motifs found among the sequences and compounds that bind the RNA motifs. In addition, the invention provides methods of treating diseases associated with a function of an RNA binding protein.
School/Discipline
Dissertation Note
Provenance
Description
Priority date Oct 23, 2003
Filing date Jul 27, 2009
Application Date: 25.10.2004
Publication Date: 13.10.2005
Publication number US20110076676 A1
Publication type Application
Application number US 12/509,856
Publication date Mar 31, 2011