Cancer-related Fatigue in Lung Cancer: A Research Agenda: An Official American Thoracic Society Research Statement
Date
2023
Authors
Bade, B.C.
Faiz, S.A.
Ha, D.M.
Tan, M.
Barton-Burke, M.
Cheville, A.L.
Escalante, C.P.
Gozal, D.
Granger, C.L.
Presley, C.J.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
American Journal of Respiratory and Critical Care Medicine, 2023; 207(5):e6-e28
Statement of Responsibility
Brett C. Bade, Saadia A. Faiz, Duc M. Ha, Miranda Tan, Margaret Barton-Burke, Andrea L. Cheville, Carmen P. Escalante, David Gozal, Catherine L. Granger, Carolyn J. Presley, Sheree M. Smith, Dawn M. Chamberlaine, Jason M. Long, Daniel J. Malone, William F. Pirl, Halley L. Robinson, Kazuhiro Yasufuku, and M. Patricia Rivera; on behalf of the American Thoracic Society Assembly on Thoracic Oncology
Conference Name
Abstract
Background: Fatigue is the most common symptom among cancer survivors. Cancer-related fatigue (CRF) may occur at any point in the cancer care continuum. Multiple factors contribute to CRF development and severity, including cancer type, treatments, presence of other symptoms, comorbidities, and medication side effects. Clinically, increasing physical activity, enhancing sleep quality, and recognizing sleep disorders are integral to managing CRF. Unfortunately, CRF is infrequently recognized, evaluated, or treated in lung cancer survivors despite more frequent and severe symptoms than in other cancers. Therefore, increased awareness and understanding of CRF are needed to improve health-related quality of life in lung cancer survivors. Objectives: 1) To identify and prioritize knowledge and research gaps and 2) to develop and prioritize research questions to evaluate mechanistic, diagnostic, and therapeutic approaches to CRF among lung cancer survivors. Methods: We convened a multidisciplinary panel to review the available literature on CRF, focusing on the impacts of physical activity, rehabilitation, and sleep disturbances in lung cancer. We used a three-round modified Delphi process to prioritize research questions. Results: This statement identifies knowledge gaps in the 1) detection and diagnostic evaluation of CRF in lung cancer survivors; 2) timing, goals, and implementation of physical activity and rehabilitation; and 3) evaluation and treatment of sleep disturbances and disorders to reduce CRF. Finally, we present the panel’s initial 32 research questions and seven final prioritized questions. Conclusions: This statement offers a prioritized research agenda to 1) advance clinical and research efforts and 2) increase awareness of CRF in lung cancer survivors.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© 2023 by the American Thoracic Society. 🔓 You may print one copy of this document at no charge. However, if you require more than one copy, you must place a reprint order. Domestic reprint orders: amy.schriver@sheridan.com; international reprint orders: louisa.mott@springer.com.