Perineuronal net structure as a non-cellular mechanism contributing to affective state: a scoping review
Files
(Published version)
Date
2024
Authors
Morphett, J.C.
Whittaker, A.L.
Reichelt, A.C.
Hutchinson, M.R.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Neuroscience and Biobehavioral Reviews, 2024; 158:105568-1-105568-13
Statement of Responsibility
J.C. Morphett, A.L. Whittaker, A.C. Reichelt, M.R. Hutchinson
Conference Name
Abstract
Affective state encompasses emotional responses to our physiology and influences how we perceive and respond within our environment. In affective disorders such as depression, cognitive adaptability is challenged, and structural and functional brain changes have been identified. However, an incomplete understanding persists of the molecular and cellular mechanisms at play in affective state. An exciting area of newly appreciated importance is perineuronal nets (PNNs); a specialised component of extracellular matrix playing a critical role in neuroprotection and synaptic plasticity. A scoping review found 24 studies demonstrating that PNNs are still a developing field of research with a promising general trend for stress in adulthood to increase the intensity of PNNs, whereas stress in adolescence reduced (potentially developmentally delayed) PNN numbers and intensity, while antidepressants correlated with reduced PNN numbers. Despite promising trends, limited research underscores the need for further exploration, emphasizing behavioral outcomes for validating affective states. Understanding PNNs’ role may offer therapeutic insights for depression and inform biomarker development, advancing precision medicine and enhancing well-being.
School/Discipline
Dissertation Note
Provenance
Description
Available online 1 February 2024
Access Status
Rights
© 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).