A simple and inexpensive preparation of [51Cr]-MAA particles
Date
2001
Authors
Tsopelas, C.
Brundell, S.
Chatterton, B.
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Journal article
Citation
Nuclear Medicine and Biology, 2001; 28(3):339-344
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Abstract
The feasibility of preparing [(51)Cr]-MAA was investigated using an MAA cold kit and commercially available sodium [(51)Cr]chromate solutions. Of different conditions tested, the best required an addition of a low level of sodium dithionite to achieve a radiolabeling efficiency of 44%. The product was purified by centrifugation to give [(51)Cr]-MAA with 99 +/- 1% radiochemical purity (RCP) comprised of >94% radioactive particles >10 microm, and resulted in a rat biodistribution with >80% in the lungs. [(51)Cr]-MAA is inexpensive, easily and conveniently prepared by this procedure.