Serum-derived bovine immunoglobulin/protein isolate in the alleviation of chemotherapy-induced mucositis
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Date
2016
Authors
Bateman, E.
Weaver, E.
Klein, G.
Wignall, A.
Wozniak, B.
Plews, E.
Mayo, B.
White, I.
Keefe, D.
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Journal article
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Supportive Care in Cancer, 2016; 24(1):377-385
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Abstract
BACKGROUND:Gastrointestinal (GI) mucositis caused by chemotherapy is associated with diarrhoea and intestinal barrier disruption caused by apoptosis, immune dysfunction and microbiome alterations. Serum-derived bovine immunoglobulin/protein isolate (SBI) has been shown to manage HIV-associated enteropathy and irritable bowel syndrome with diarrhoea (IBS-D). We investigated in a rat model whether SBI was effective in alleviating symptoms of irinotecan-induced GI mucositis. METHODS:Animals were gavaged with 250 or 500 mg/kg of SBI twice daily for 4 days, before intraperitoneal administration of 200 mg/kg irinotecan. Twice daily gavaging of SBI continued for 6 days post-irinotecan. Animals were monitored for bodyweight changes and incidence of diarrhoea and clinical symptoms of stress. Tissues and blood samples were collected at necropsy 6 h, and 2, 4 and 6 days post-irinotecan. H&E-stained colon and jejunum were analysed for histological damage. RESULTS:The overall incidence, severity and duration of diarrhoea, and clinical symptoms of mucositis were decreased in irinotecan-treated animals that had received SBI. Animals receiving 500 mg/kg SBI also tended to lose less bodyweight than animals treated only with irinotecan (P > 0.10). SBI-gavaged animals had less pronounced irinotecan-induced changes in neutrophil (P = 0.04959) and lymphocyte (P = 0.0035) levels, and lower tissue damage scores than those receiving irinotecan alone (P < 0.0001). CONCLUSIONS:Twice daily oral gavage of SBI was well-tolerated and reduced the incidence, severity and duration of irinotecan-induced mucositis. SBI was associated with less pronounced changes in inflammatory cell levels and tissue damage to colon and jejunum. Ongoing experiments aim to investigate the mechanisms of SBI-associated gastrointestinal protection.
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Link to a related website: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4669373&blobtype=pdf, Open Access via Unpaywall
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Copyright 2015 The Author(s)
Access Condition Notes: This article is distributed under the terms of the CreativeCommons Attribution-Non Commercial 4.0 International License (http://creative commons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium,provided you give appropriate credit to the original author(s)and the source, provide a link to the Creative Commons license