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Screening for sickle cell and thalassaemia in primary care: A cost-effectiveness study

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dc.contributor.authorBryan, S.
dc.contributor.authorDormandy, E.
dc.contributor.authorRoberts, T.
dc.contributor.authorAdes, A.
dc.contributor.authorBarton, P.
dc.contributor.authorJuarez-Garcia, A.
dc.contributor.authorAndronis, L.
dc.contributor.authorKarnon, J.
dc.contributor.authorMarteau, T.
dc.date.issued2011
dc.description.abstractBackground: Haemoglobinopathies, including sickle cell disease and thalassaemia (SCT), are inherited disorders of haemoglobin. Antenatal screening for SCT rarely occurs before 10 weeks of pregnancy. Aim: To explore the cost-effectiveness of offering SCT screening in a primary care setting, during the pregnancy confirmation visit. Design and setting: A model-based cost-effectiveness analysis of inner-city areas with a high proportion of residents from ethnic minority groups. Method: Comparison was made of three SCT screening approaches: `primary care parallel' (primary care screening with test offered to mother and father together); `primary care sequential (primary care screening with test offered to the mother and then the father only if the mother is a carrier); and `midwife care' (sequential screening at the first midwife consultation). The model was populated with data from the SHIFT (Screening for Haemoglobinopathies In First Trimester) trial and other sources. Results: Compared to midwife care, primary care sequential had a higher NHS cost of £34 000 per 10 000 pregnancies (95% confidence interval [CI] = £15 000 to £51 000) and an increase of 2623 women screened (95% CI: 1359 to 4495), giving a cost per additional woman screened by 10 weeks of £13. Primary care parallel was dominated by primary care sequential, with both higher costs and fewer women screened. Conclusion: The policy judgement is whether an earlier opportunity for informed reproductive choice has a value of at least £13. Further work is required to understand the value attached to earlier informed reproductive choices.
dc.description.statementofresponsibilityStirling Bryan, Elizabeth Dormandy, Tracy Roberts, Anthony Ades, Pelham Barton, Ariadna Juarez-Garcia, Lazaros Andronis, Jonathan Karnon and Theresa M. Marteau
dc.identifier.citationBritish Journal of General Practice, 2011; 61(591):e620-e627
dc.identifier.doi10.3399/bjgp11X601325
dc.identifier.issn0960-1643
dc.identifier.issn1478-5242
dc.identifier.orcidKarnon, J. [0000-0003-3220-2099]
dc.identifier.urihttp://hdl.handle.net/2440/71301
dc.language.isoen
dc.publisherRoyal Coll General Practitioners
dc.rights© Royal College of General Practitioners
dc.source.urihttps://doi.org/10.3399/bjgp11x601325
dc.subjectAntenatal diagnosis
dc.subjectcost effectiveness
dc.subjecthemoglobin S disease
dc.subjectprimary care
dc.subjectthalassemia
dc.titleScreening for sickle cell and thalassaemia in primary care: A cost-effectiveness study
dc.typeJournal article
pubs.publication-statusPublished

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