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Tubal factor infertility with prior ectopic pregnancy: a double whammy? A retrospective cohort study of 2,892 women

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dc.contributor.authorCai, H.
dc.contributor.authorMol, B.W.
dc.contributor.authorLi, P.
dc.contributor.authorLiu, X.
dc.contributor.authorWatrelot, A.
dc.contributor.authorShi, J.
dc.date.issued2020
dc.description.abstractOBJECTIVE: To investigate the impact of a history of previous naturally conceived tubal ectopic pregnancy (TEP) on subsequent IVF/intracytoplasmic sperm injection (ICSI) pregnancy and perinatal outcomes. DESIGN: Retrospective cohort study. SETTING: Reproductive medicine center in a tertiary hospital. PATIENT(S): A total of 2,892 women with tubal infertility undergoing the first fresh IVF/ICSI cycle. INTERVENTION(S): Women were stratified into three groups according to the type of previous naturally conceived pregnancy: TEP, intrauterine pregnancy (IUP), and no pregnancy. MAIN OUTCOMES MEASURE(S): Pregnancy and neonatal outcomes were analyzed for each cohort and stratified into the following categories based on female age: <30 years, 30-35 years, and ≥35 years. RESULT(S): Of the 2,892 patients with tubal factor infertility, 511 (17.7%) women had a history of TEP, 1,044 (36.1%) had prior IUP, and 1,337 (46.2%) had never been pregnant. Couples with an initial TEP tended to be younger and had experienced a shorter duration of infertility. Across the whole cohort, the optimal live birth rate decreased in older age groups. Live birth rates stratified by maternal age (<30, 30-35, ≥35 years) did not differ between the TEP group (59.9%, 53.7%, 45.5%) and the IUP (62.0%, 53.8%, 40.6%) and no pregnancy group (56.7%, 54.4%, 45.6%). This did not change after adjusting for confounders such as age and years of infertility. Previous treatment of TEP with salpingectomy, salpingostomy, or medical treatment did not significantly affect subsequent fertility outcomes. The rates of preterm and low birth weight after TEP were also not significantly higher than in women with a previous IUP. CONCLUSION(S): Fertility history, including previous TEP, does not influence the probability of live birth after IVF/ICSI in women with tubal factor infertility.
dc.description.statementofresponsibilityHe Cai, Ben W.Mol, Ping Li, Xitong Liu, Antoine Watrelot, Juanzi Shi
dc.identifier.citationFertility and Sterility, 2020; 113(5):1032-1038
dc.identifier.doi10.1016/j.fertnstert.2019.12.036
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.orcidMol, B.W. [0000-0001-6887-0262] [0000-0001-8337-550X]
dc.identifier.urihttp://hdl.handle.net/2440/128729
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1082548
dc.rights© 2019 American Society for Reproductive Medicine, Published by Elsevier Inc.
dc.source.urihttps://doi.org/10.1016/j.fertnstert.2019.12.036
dc.subjectCohort study
dc.subjectin vitro fertilization
dc.subjectlive birth
dc.subjectneonatal outcome
dc.subjecttubal ectopic pregnancy
dc.titleTubal factor infertility with prior ectopic pregnancy: a double whammy? A retrospective cohort study of 2,892 women
dc.typeJournal article
pubs.publication-statusPublished

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