Beneficial autoimmunity in type 1 diabetes mellitus

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dc.contributor.authorHauben, E.
dc.contributor.authorRoncarolo, M.
dc.contributor.authorNevo, U.
dc.contributor.authorSchwartz, M.
dc.date.issued2005
dc.description.abstractThe trigger that leads to the pathogenesis of type 1 diabetes is currently unknown. It is well established that the pathophysiology of the disease is biphasic. In the first stage, leukocytes infiltrate the pancreatic islets in a response that does not cause damage. In the second phase, which occurs only in diabetes-prone individuals and strains, autoreactive T cells acquire aggressive potential and destroy the majority of the pancreatic islets. Rodents and humans exhibit a physiological ripple of apoptotic beta-cell death shortly after birth, which induces an adaptive autoimmune response towards islet-antigens, both in diabetes-prone non-obese diabetic (NOD) mice and in mice that do not develop diabetes. Here, we propose that the early T cell-mediated autoimmune response towards islet-antigens is physiological, purposeful and beneficial.
dc.description.statementofresponsibilityEhud Hauben, Maria Grazia Roncarolo, Uri Nevo and Michal Schwartz
dc.identifier.citationTrends in Immunology, 2005; 26(5):248-253
dc.identifier.doi10.1016/j.it.2005.03.004
dc.identifier.issn1471-4906
dc.identifier.issn1471-4981
dc.identifier.orcidHauben, E. [0000-0002-6062-411X]
dc.identifier.urihttp://hdl.handle.net/2440/82240
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.rights© 2005 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.it.2005.03.004
dc.subjectB-Lymphocytes
dc.subjectT-Lymphocyte Subsets
dc.subjectAnimals
dc.subjectHumans
dc.subjectDiabetes Mellitus, Type 1
dc.subjectApoptosis
dc.subjectCell Differentiation
dc.subjectAutoimmunity
dc.subjectImmune Tolerance
dc.subjectHomeostasis
dc.titleBeneficial autoimmunity in type 1 diabetes mellitus
dc.typeJournal article
pubs.publication-statusPublished

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