Biomimetic total synthesis of (±)-garcibracteatone
Date
2012
Authors
Pepper, H.
Lam, H.
Bloch, W.
George, J.
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Journal article
Citation
Organic Letters, 2012; 14(19):5162-5164
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Henry P. Pepper, Hiu C. Lam, Witold M. Bloch, and Jonathan H. George
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Abstract
The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction.
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Copyright © 2012 American Chemical Society