Trough concentrations of vancomycin: adult therapeutic targets are not appropriate for children
Date
2012
Authors
Gordon, C.
Thompson, C.
Carapetis, J.
Turnidge, J.
Kilburn, C.
Currie, B.
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Journal article
Citation
The Pediatric Infectious Disease Journal, 2012; 31(12):1269-1271
Statement of Responsibility
Claire L. Gordon, Chantelle Thompson, Jonathan R. Carapetis, John Turnidge, Charles Kilburn and Bart J. Currie
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Abstract
Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.
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Copyright: © 2012 Lippincott Williams & Wilkins, Inc.