Female endurance athletes: smaller hearts but similar relationship between ventricular size, fitness and fibrosis as male athletes
Date
2025
Authors
Rowe, S.
Janssens, K.
Mitchell, A.
D’Ambrosio, P.
De Paepe, J.
Van Soest, S.
Calvo-Lopez, M.
Cullen, O.
Spencer, L.
Dausin, C.
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Journal article
Citation
British Journal of Sports Medicine, 2025; 59(17):1211-1218
Statement of Responsibility
Stephanie Rowe, Kristel Janssens, Amy Mitchell, Paolo D'Ambrosio, Jarne De Paepe, Sofie Van Soest, Margarita Calvo-Lopez, Oscar Cullen, Luke Spencer, Christophe Dausin, Olivier Ghekiere, Jan Bogaert, Lieven Herbots, Youri Bekhuis, Rik Pauwels, Rik Willems, Hein Heidbuchel, Guido Claessen, André La Gerche, on behalf of the Pro@Heart Consortium
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Abstract
Objectives: Exercise-induced cardiac remodelling is well described in male athletes but incompletely understood in females. This study aimed to examine sex differences in cardiac structure, function and fibrosis relative to fitness and to determine reference ranges for ’normal’ chamber size in a large cohort of healthy male and female highly trained endurance athletes. Methods: This multicentre international study used cardiac MRI and cardiopulmonary exercise testing (VO₂peak) to assess sex-specific relationships between measures of biventricular chamber size, function, fibrosis and VO₂peak. Results: Of the 364 endurance athletes included, 36.5% were female. Compared with males, female athletes achieved lower VO₂peak (51 (40–57) vs 59 (41–65) mL/kg/min, p<0.001), had smaller absolute and body surface area (BSA)-indexed left and right end-diastolic volumes (LVEDV, respectively) but similar volumes when indexed to fat-free mass. Both sexes showed a strong association between LVEDV and VO₂peak (r=0.60–0.66) and a similar coefficient describing the linear relationship between VO₂peak and LVEDV (Females: VO₂peak(mL/min)=12.1×LVEDV+963.9; males: VO2peak=15.3×LVEDV+806.8, p=0.100) and BSA-indexed LVEDV (females: VO₂peak (mL/kg/min)=0.37×LVEDV/BSA+12.5; males: VO₂peak=0.51×LVEDV/BSA-1.2, p=0.059). There was no difference between right ventricular (RV) measures and VO₂peak; however, males had 3.8 times higher odds of reduced RV ejection fraction. Prevalent myocardial scar was similar for both female (14.2%) and male (19.9%) athletes (p=0.180). Conclusions: Female and male athletes demonstrate similar cardiac remodelling relative to fitness and no sex difference in myocardial scar. The female athlete’s heart can show profound adaptation, and previous assertions that female hearts have lesser capacity for remodelling should be reappraised.
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© Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group