Granulomatous disease in selective IgA deficiency
Date
2007
Authors
Limaye, V.
Lu, T.
Ang, E.
Krishnan, A.
Hissaria, P.
Gillis, D.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Aplar Journal of Rheumatology, 2007; 10(3):248-252
Statement of Responsibility
Vidya Limaye, Tim Lu, Eugene Ang, Amirtharajan Krishnan, Pravin Hissaria and David Gillis
Conference Name
Abstract
Although common variable immunodeficiency (CVID) is sometimes associated with sarcoidosis/granulomatous disease, there have only been isolated reports of selective immunoglobulin A (IgA) deficiency and granulomatous disease. We present a patient with IgA deficiency who developed Heerfordt syndrome, a variant of neurosarcoidosis. This specific entity has not been previously reported to occur in IgA deficiency. Our case expands the reported associations of IgA deficiency and provides another example to the paucity of reported cases of sarcoidosis occurring in patients with IgA deficiency. As CVID and IgA deficiency have common underlying genetic factors, such an association is biologically plausible.