Therapeutic potential of ketone bodies for patients with cardiovascular disease: JACC focus seminar
Date
2021
Authors
Yurista, S.R.
Chong, C.-R.
Badimon, J.J.
Kelly, D.P.
de Boer, R.A.
Westenbrink, B.D.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of the American College of Cardiology, 2021; 77(13):1660-1669
Statement of Responsibility
Salva R.Yurista, Cher-RinChong, Juan J.Badimon, Daniel P.Kelly, Rudolf A.de Boer, B. Daan Westenbrink
Conference Name
Abstract
Metabolic perturbations underlie a variety of cardiovascular disease states; yet, metabolic interventions to prevent or treat these disorders are sparse. Ketones carry a negative clinical stigma as they are involved in diabetic ketoacidosis. However, evidence from both experimental and clinical research has uncovered a protective role for ketones in cardiovascular disease. Although ketones may provide supplemental fuel for the energy-starved heart, their cardiovascular effects appear to extend far beyond cardiac energetics. Indeed, ketone bodies have been shown to influence a variety of cellular processes including gene transcription, inflammation and oxidative stress, endothelial function, cardiac remodeling, and cardiovascular risk factors. This paper reviews the bioenergetic and pleiotropic effects of ketone bodies that could potentially contribute to its cardiovascular benefits based on evidence from animal and human studies.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.