Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women

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dc.contributor.authorShahrbabaki, S.S.
dc.contributor.authorLinz, D.
dc.contributor.authorHartmann, S.
dc.contributor.authorRedline, S.
dc.contributor.authorBaumert, M.
dc.date.issued2021
dc.description.abstractAims: To quantify the arousal burden (AB) across large cohort studies and determine its association with long-term cardiovascular (CV) and overall mortality in men and women. Methods and results: We measured the AB on overnight polysomnograms of 2782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF) and 2221 men and 2574 women in the Sleep Heart Health Study (SHHS). During 11.2 ± 2.1 years of follow-up in MrOS, 665 men died, including 236 CV deaths. During 6.4 ± 1.6 years of follow-up in SOF, 105 women died, including 47 CV deaths. During 10.7 ± 3.1 years of follow-up in SHHS, 987 participants died, including 344 CV deaths. In women, multivariable Cox proportional hazard analysis adjusted for common confounders demonstrated that AB is associated with all-cause mortality [SOF: hazard ratio (HR) 1.58 (1.01–2.42), P = 0.038; SHHS-women: HR 1.21 (1.06–1.42), P = 0.012] and CV mortality [SOF: HR 2.17 (1.04–4.50), P = 0.037; SHHS-women: HR 1.60 (1.12–2.28), P = 0.009]. In men, the association between AB and all-cause mortality [MrOS: HR 1.11 (0.94–1.32), P = 0.261; SHHS-men: HR 1.31 (1.06–1.62), P = 0.011] and CV mortality [MrOS: HR 1.35 (1.02–1.79), P = 0.034; SHHS-men: HR 1.24 (0.86–1.79), P = 0.271] was less clear. Conclusions: Nocturnal AB is associated with long-term CV and all-cause mortality in women and to a lesser extent in men.
dc.description.statementofresponsibilitySobhan Salari Shahrbabaki, Dominik Linz, Simon Hartmann, Susan Redline and Mathias Baumert
dc.identifier.citationEuropean Heart Journal, 2021; 42(21):2088-2099
dc.identifier.doi10.1093/eurheartj/ehab151
dc.identifier.issn0195-668X
dc.identifier.issn1522-9645
dc.identifier.orcidLinz, D. [0000-0003-4893-0824]
dc.identifier.orcidHartmann, S. [0000-0001-9689-0594]
dc.identifier.orcidBaumert, M. [0000-0003-2984-2167]
dc.identifier.urihttp://hdl.handle.net/2440/131687
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.relation.granthttp://purl.org/au-research/grants/arc/DP0663345
dc.rightsPublished on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.
dc.source.urihttps://doi.org/10.1093/eurheartj/ehab151
dc.subjectCardiovascular diseases
dc.titleSleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women
dc.typeJournal article
pubs.publication-statusPublished

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