Pickering emulsions for dermal delivery
Date
2011
Authors
Simovic, S.
Ghouchi Eskandar, N.
Prestidge, C.A.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Drug Delivery Science and Technology, 2011; 21(1):123-133
Statement of Responsibility
Conference Name
Abstract
We report on the stability, structural and dermal delivery characteristics of Pickering emulsions composed of medium chain triglycerides, hydrophilic nanoparticles ~ 50 nm and lipophilic amphiphiles in the oil phase. The emulsion stability and structural properties were analyzed as a function of the charge and concentration of the lipophilic amphiphiles, concentration and initial loading phase of nanoparticles. The determination of the chemical stability of model drug all-trans-retinol confirmed that nanoparticle layers can be engineered to enhance the shelf-life of unstable lipophilic molecules. The penetration/permeation behavior of Pickering emulsions was estimated from an ex vivo porcine skin model using all-trans-retinol and a fluorescent probe. The skin retention and depth of the penetration can be significantly increased (p 0.05), up to a skin depth of ~ 290 um by Pickering emulsions in comparison to the control emulsions. The skin permeation of nanoparticles was negligible (<1 ugmL-1 after a 6 h exposure time) which demonstrated the potential of Pickering emulsions for epidermal/dermal skin targeting.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2011 Elsevier