Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma
Date
2021
Authors
Meakin, A.S.
Morrison, J.L.
Bradshaw, E.L.
Holman, S.L.
Saif, Z.
Gatford, K.L.
Wallace, M.J.
Bischof, R.J.
Moss, T.J.M.
Clifton, V.L.
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Type:
Journal article
Citation
Placenta, 2021; 104:232-235
Statement of Responsibility
Ashley S. Meakin, Janna L. Morrison, Emma L. Bradshaw, Stacey L. Holman, Zarqa Saif, Kathryn L. Gatford, Megan J. Wallace, Robert J. Bischof, Timothy J.M. Moss, Vicki L. Clifton
Conference Name
Abstract
Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development.
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Crown Copyright © 2021 Published by Elsevier Ltd. All rights reserved.