Resting-state networks in tinnitus: a scoping review
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Date
2022
Authors
Kok, T.E.
Domingo, D.
Hassan, J.
Vuong, A.
Hordacre, B.
Clark, C.
Katrakazas, P.
Shekhawat, G.S.
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Clinical Neuroradiology, 2022; 32(4):903-922
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Abstract
Chronic subjective tinnitus is the constant perception of a sound that has no physical source. Brain imaging studies show alterations in tinnitus patients’ resting-state networks (RSNs). This scoping review aims to provide an overview of resting-state fMRI studies in tinnitus, and to evaluate the evidence for changes in different RSNs. A total of 29 studies were included, 26 of which found alterations in networks such as the auditory network, default mode network, attention networks, and visual network; however, there is a lack of reproducibility in the field which can be attributed to the use of different regions of interest and analytical methods per study, and tinnitus heterogeneity. Future studies should focus on replication by using the same regions of interest in their analysis of resting-state data, and by controlling adequately for potential confounds. These efforts could potentially lead to the identification of a biomarker for tinnitus in the future.
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Data source: Supplementary information, https://doi.org/10.1007/s00062-022-01170-1
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Copyright 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4. 0/)
Access Condition Notes: Open Access funding enabled and organized by CAUL and its Member Institutions