Dietary and ontogenic regulation of fatty acid desaturase and elongase expression in broiler chickens
Date
2013
Authors
Jing, M.
Gakhar, N.
Gibson, R.
House, J.
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Journal article
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Prostaglandins, Leukotrienes and Essential Fatty Acids, 2013; 89(2):107-113
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M. Jing, N. Gakhar, R.A. Gibson, J.D. House
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Abstract
Effects of diet and ontogeny on the expression of fatty acid desaturases and elongases were examined in broiler chickens. In Study 1, 120 day-old male chicks received one of six diets with LA:ALA ranging from 46:4 to 16:34, for 33 days. Total n-6 PUFA decreased, and n-3 PUFA increased in response to a decrease in the dietary LA:ALA. FADS1, FADS2, ELOVL2 and ELOVL5 mRNAs were highest (P<0.05) in birds fed lower LA:ALA diets. In Study 2, 60 day-old male chicks were fed a basal diet, and liver samples were collected on day of hatch, and on days 2, 7, 14, 21 and 35 post-hatch. Total n-6 and n-3 PUFA increased (P<0.01) from days 7 to days 21. FADS1, FADS2 and ELOVL2 mRNAs generally increased (P<0.01) with age. These findings provide evidence for the dietary and developmental regulation of PUFA metabolism in broiler chickens.
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Copyright © 2013 Elsevier Ltd. All rights reserved.