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The diversity and breadth of cancer cell fatty acid metabolism

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dc.contributor.authorNagarajan, S.R.
dc.contributor.authorButler, L.M.
dc.contributor.authorHoy, A.J.
dc.date.issued2021
dc.description.abstractTumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation and cell-extrinsic influences, including growth factor and nutrient availability. Alongside glucose and amino acid metabolism, fatty acid metabolism supports tumorigenesis and disease progression through a range of processes including membrane biosynthesis, energy storage and production, and generation of signaling intermediates. Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the various inputs and outputs of the intracellular free fatty acid pool, and the numerous ways that these pathways influence disease behavior.
dc.description.statementofresponsibilityShilpa R. Nagarajan, Lisa M. Butler, and Andrew J. Hoy
dc.identifier.citationCancer & Metabolism, 2021; 9(1):1-28
dc.identifier.doi10.1186/s40170-020-00237-2
dc.identifier.issn2049-3002
dc.identifier.issn2049-3002
dc.identifier.orcidButler, L.M. [0000-0003-2698-3220]
dc.identifier.urihttps://hdl.handle.net/2440/140079
dc.language.isoen
dc.publisherBMC
dc.relation.granthttp://purl.org/au-research/grants/arc/FT130101004
dc.rights© The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.source.urihttps://doi.org/10.1186/s40170-020-00237-2
dc.subjectCellular membrane
dc.subjectDe novo synthesis
dc.subjectFatty acid
dc.subjectLipid
dc.subjectLipid droplets
dc.subjectMitochondria
dc.subjectOxidation
dc.subjectPeroxisome
dc.titleThe diversity and breadth of cancer cell fatty acid metabolism
dc.typeJournal article
pubs.publication-statusPublished

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