Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Date
2013
Authors
Ripke, S.
O'Dushlaine, C.
Chambert, K.
Moran, J.L.
Lee, S.H.
Sullivan, P.F.
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Nature Genetics, 2013; 45(10):1150-1159
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Abstract
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder.
Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
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Data source: Supplementary information, https://doi.org/10.1038/ng.2742
Link to a related website: http://europepmc.org/articles/pmc3827979?pdf=render, Open Access via Unpaywall
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Copyright 2013 Nature America