The impact of acetylcholinesterase inhibitors on ileus and gut motility following abdominal surgery: a clinical review

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dc.contributor.authorTraeger, L.
dc.contributor.authorKroon, H.M.
dc.contributor.authorBedrikovetski, S.
dc.contributor.authorMoore, J.W.
dc.contributor.authorSammour, T.
dc.date.issued2022
dc.description.abstractPostoperative ileus is a common complication in the days following colorectal surgery occurring in up to 50% of patients. When prolonged, this complication results in significant morbidity and mortality, doubling the total costs of hospital stay. Postoperative ileus (POI) results from the prolonged inflammatory phase that is mediated in part by the cholinergic anti-inflammatory pathway. Acetylcholinesterase inhibitors, such as neostigmine and pyridostigmine, delay the degradation of acetylcholine at the synaptic cleft. This increase in acetylcholine has been shown to increase gut motility. They have been effective in the treatment of acute colonic pseudo-obstruction, but there is limited evidence for the use of these medications for reducing the incidence of POI. This review was conducted to summarise the evidence of acetylcholinesterase inhibitors’ effect on gut motility and discuss their potential use as part of an enhanced recovery protocols to prevent or treat POI.
dc.description.statementofresponsibilityLuke Traeger, Hidde M. Kroon, Sergei Bedrikovetski, James W. Moore, and Tarik Sammour
dc.identifier.citationANZ Journal of Surgery, 2022; 92(1-2):69-76
dc.identifier.doi10.1111/ans.17418
dc.identifier.issn1445-1433
dc.identifier.issn1445-2197
dc.identifier.orcidTraeger, L. [0000-0002-0327-7334]
dc.identifier.orcidKroon, H.M. [0000-0002-8923-7527]
dc.identifier.orcidBedrikovetski, S. [0000-0001-9330-625X]
dc.identifier.orcidSammour, T. [0000-0002-4918-8871]
dc.identifier.urihttps://hdl.handle.net/2440/140049
dc.language.isoen
dc.publisherWiley
dc.rights© 2021 Royal Australasian College of Surgeons.
dc.source.urihttps://doi.org/10.1111/ans.17418
dc.subjectcolorectal surgery; ileus; neostigmine; pyridostigmine
dc.subject.meshHumans
dc.subject.meshIleus
dc.subject.meshPostoperative Complications
dc.subject.meshAcetylcholinesterase
dc.subject.meshCholinesterase Inhibitors
dc.subject.meshDigestive System Surgical Procedures
dc.subject.meshColorectal Surgery
dc.titleThe impact of acetylcholinesterase inhibitors on ileus and gut motility following abdominal surgery: a clinical review
dc.typeJournal article
pubs.publication-statusPublished online

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