Trefoil factor family: unresolved questions and clinical perspectives
Date
2019
Authors
Braga Emidio, N.
Hoffmann, W.
Brierley, S.M.
Muttenthaler, M.
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Journal article
Citation
Trends in Biochemical Sciences, 2019; 44(5):387-390
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Nayara Braga Emidio, Werner Hoffmann, Stuart M.Brierley, Markus Muttenthaler
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Abstract
The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.
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© 2019 Elsevier Ltd. All rights reserved.