Focal myelin swellings and tomacula in anti-MAG IgM paraproteinaemic neuropathy: Novel teased nerve fiber studies
Date
2001
Authors
Cai, Z.
Cash, K.
Swift, J.
Sutton-Smith, P.
Robinson, M.
Thompson, P.
Blumbergs, P.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of the Peripheral Nervous System, 2001; 6(2):95-101
Statement of Responsibility
Zhao Cai, Kathy Cash, Jeffrey Swift, Peter Sutton-Smith, Martin Robinson, Philip D. Thompson, Peter C. Blumbergs
Conference Name
Abstract
Focal myelin swellings and tomacula in teased nerve fibers from a case of IgM anti-myelin-associated glycoprotein (MAG) paraproteinaemic neuropathy were examined using a novel technique. Five different morphologic abnormalities were identified—myelin sheath outfolding, myelin sheath infolding, enlargement of the adaxonal space, myelin degeneration, multiple increased concentric loops—and a combination of these structural abnormalities often occur in association with myelin degeneration. Similar structural changes were found in externally normal segments of teased fibers without evidence of myelin swelling or tomacula from the same case. These structural abnormalities are consistent with a disturbance of the normal adhesion functions of MAG in the maintenance of axon-myelin relationships.
School/Discipline
Dissertation Note
Provenance
Description
The definitive version is available at www.blackwell-synergy.com Copyright © 2001 Periphal Nerve Society, Inc.