Focal myelin swellings and tomacula in anti-MAG IgM paraproteinaemic neuropathy: Novel teased nerve fiber studies

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dc.contributor.authorCai, Z.
dc.contributor.authorCash, K.
dc.contributor.authorSwift, J.
dc.contributor.authorSutton-Smith, P.
dc.contributor.authorRobinson, M.
dc.contributor.authorThompson, P.
dc.contributor.authorBlumbergs, P.
dc.date.issued2001
dc.descriptionThe definitive version is available at www.blackwell-synergy.com Copyright © 2001 Periphal Nerve Society, Inc.
dc.description.abstractFocal myelin swellings and tomacula in teased nerve fibers from a case of IgM anti-myelin-associated glycoprotein (MAG) paraproteinaemic neuropathy were examined using a novel technique. Five different morphologic abnormalities were identified—myelin sheath outfolding, myelin sheath infolding, enlargement of the adaxonal space, myelin degeneration, multiple increased concentric loops—and a combination of these structural abnormalities often occur in association with myelin degeneration. Similar structural changes were found in externally normal segments of teased fibers without evidence of myelin swelling or tomacula from the same case. These structural abnormalities are consistent with a disturbance of the normal adhesion functions of MAG in the maintenance of axon-myelin relationships.
dc.description.statementofresponsibilityZhao Cai, Kathy Cash, Jeffrey Swift, Peter Sutton-Smith, Martin Robinson, Philip D. Thompson, Peter C. Blumbergs
dc.identifier.citationJournal of the Peripheral Nervous System, 2001; 6(2):95-101
dc.identifier.doi10.1046/j.1529-8027.2001.01013
dc.identifier.issn1085-9489
dc.identifier.issn1529-8027
dc.identifier.urihttp://hdl.handle.net/2440/9660
dc.language.isoen
dc.publisherBlackwell Science Inc.
dc.subjectMyelin Sheath
dc.subjectNerve Fibers
dc.subjectSural Nerve
dc.subjectHumans
dc.subjectDemyelinating Diseases
dc.subjectTremor
dc.subjectPeripheral Nervous System Diseases
dc.subjectParaproteinemias
dc.subjectImmunoglobulin M
dc.subjectMyelin-Associated Glycoprotein
dc.subjectMicroscopy, Electron
dc.subjectAged
dc.subjectMale
dc.titleFocal myelin swellings and tomacula in anti-MAG IgM paraproteinaemic neuropathy: Novel teased nerve fiber studies
dc.typeJournal article
pubs.publication-statusPublished

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