2026-09-20T21:32:21Zhttps://digital.library.adelaide.edu.au/server/oai/request

oai:digital.library.adelaide.edu.au:2440/1337842026-06-12T07:42:58Zcom_2440_14759col_2440_14760

Corrigan, Frances Collins-Praino, Lyndsey Mustafa, Sanam Guglietti, Bianca Laura School of Medicine 2021 https://hdl.handle.net/2440/133784 Whilst Parkinson’s disease (PD) is primarily characterised as a motor disorder, non-motor symptoms represent a significant burden to the PD population. These symptoms include anxiety, depression, fatigue and cognitive impairment (CI), with CI representing the single biggest predictor of quality of life, mortality and caregiver burden for PD patients. Impairments range from mild-severe and dementia and involve dysfunction in domains such as learning, memory, response inhibition, visuospatial function and executive function. Unfortunately, current treatments for CI in PD provide variable symptomatic relief but do nothing to alter disease progression. To this end, the aim of this thesis is to explore novel pharmacological and non-pharmacological treatment strategies for cognitive dysfunction in PD. The first part of the thesis will investigate the role of a potential novel pathological target, Fyn kinase, in the pathophysiology of neurological disease, examine its distribution in key anatomical regions of the PD brain, and evaluate the potential of inhibition of this target for the treatment of cognitive impairment in PD. The second part of this thesis will instead turn to a non-pharmacological strategy, exploring the utility of cognitive training (CT) in PD and engaging in a co-design process for a “Serious Games” based strategy to deliver CT in this population. Thesis (Ph.D.) -- University of Adelaide, School of Medical School, 2021 en Parkinson's disease neurodegeneration neuroinflammation cognitive impairment cognitive training Targeting Cognitive Impairment in Parkinson’s Disease: Novel Pharmacological and Non- Pharmacological Approaches Thesis This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legalsopen.access