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Diener, Kerrilyn Alemie, Markos Negash 2025-12-11 https://hdl.handle.net/2440/150404 xx, 237 pages This doctoral research investigates how biomaterials can be designed to guide the immune system’s response in beneficial ways. By studying how the immune system interacts with different model implant materials, the work reveals strategies to modulate immune response, promote healing and improve the integration of medical implants. These findings contribute to the development of smarter biomaterials that work in harmony with the body’s natural defences, offering new possibilities for regenerative medicine and immune modulation. Thesis (PhD (Biomaterials Engineering and Nanomedicine)) -- University of South Australia, UniSA Clinical and Health Sciences, 2025 en University of South Australia Designing Immune-Instructive Biomaterials: The Interplay of Biomaterial surface, IgG Unfolding, and Macrophage Modulation Thesis This electronic version is made publicly available by the University of South Australia in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please notify the University copyright officer by emailing copyright@adelaide.edu.auopen.access