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Morrison, Janna Bertossa, Melanie 2026-01-29 https://hdl.handle.net/2440/150701 xxvi, 275 pages This thesis utilised animal models of human pregnancy with cardiac maturation timing similar to humans (baboon, sheep, guinea pig) to understand how exposure to a suboptimal diet (under- and overnutrition) at different timings, severities, and durations impacts growth, hormonal, metabolic, and contractile profiles within the fetal heart. Across studies, it was highlighted that high-risk cardiac phenotypes are present even with normal fetal body weight, challenging the traditional view that birth weight is a predictor of cardiovascular disease (CVD) risk. Mechanisms underlying the fetal origins of CVD were identified that could be targeted for the development of future interventions. This included reduced cardiac thyroid hormone concentrations, increased markers of pathological hypertrophy and impaired cardiometabolic status. Thesis (PhD (Medical Science)) -- University of South Australia, UniSA Clinical and Health Sciences, 2026 en University of South Australia Maternal diet fetal heart intervention targets The impact of suboptimal maternal diet on fetal heart development: Identifying targets for intervention Thesis This electronic version is made publicly available by the University of South Australia in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please notify the University copyright officer by emailing copyright@adelaide.edu.auopen.access