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Bryant, Katherine J. (Katherine Jane), 1962- Dept. of Biochemistry 1995 http://hdl.handle.net/2440/19074 Bibliography: leaves 112-140. xi, 141, [39] leaves, [8] leaves of plates : ill. ; 30 cm. The aims of this thesis are to determine the initial cleavage sites of purified pepsin in long-R3-IGF-I and assess whether the resulting cleavages affect biological activity, to design and produce analogues of long-R3-IGF-I which contain amino acid substitutions, to characterise the resulting analogues for pepsin resistance and retention of biological activity and to assess the stability of the long-R3-IGF-I analogues under in vivo conditions using luminal stomach flushings. Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry, 1996 107449 bytes application/pdf en Somatomedin. Insulin Derivatives. Gastrointestinal hormones. Porcine somatotropin. Growth factors. Design, production and characterisation of IGF-I analogues with increased gastric stability / by Katherine J. Bryant. Thesis This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legalsopen.access