2026-09-23T10:31:37Zhttps://digital.library.adelaide.edu.au/server/oai/request

oai:digital.library.adelaide.edu.au:2440/216772018-06-05T05:25:54Zcom_2440_14759col_2440_14760

Coates, Patrick Toby Hewlett Dept. of Medicine 2001 http://hdl.handle.net/2440/21677 Bibliography: leaves 151-186. 187 leaves, [26] leaves of plates : ill. (chiefly col.) 29 cm. Studies the capacity of dendritic cells transduced with the immunosuppressive gene construct adenoviral interleukin-10 to inhibit alloimmune responses in both small and large animal transplantation models. There is promising in vitro evidence for gene therapy to modify dendritic cell function, which in small animal models can modify skin graft rejection. In large animals, genetically modified dendritic cells alone were not capable of prolongation of allograft survival, suggesting that these cells may require adjuvant immunosuppressive therapy to be used in future protocols. Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2001 231473 bytes application/pdf en Gene therapy studies of Adenoviral IL-10 transduced Dendritic cells in allotransplantation / by Toby Coates. Thesis Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text. This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals.open.access