Grant, C.Summersides, G.Kuchel, T.2006-07-262006-07-262001Laboratory Animals, 2001; 35(3):277-2810023-67721758-1117http://hdl.handle.net/2440/14751The efficacy of continuous low-dose xylazine infusion following an initial loading dose in providing analgesia in sheep was examined using an algesimetry method based on a leg lifting response to an electrical stimulus. Sheep received a 5 mg intramuscular injection of xylazine followed by continuous infusion of intravenous xylazine (2 mg/h) for 90 min. This treatment resulted in significant increases in the level of current required to elicit a leg lifting response (287% of baseline) and steady state analgesia was maintained from 10 min after the start of the infusion until the end of the experimental period. This protocol appears to be a simple and effective regimen for providing steady state analgesia in sheep.enAnimalsSheepXylazineAdrenergic alpha-AgonistsAnalgesiaInjections, IntramuscularMaleJournal article002001073310.1258/00236770119116060001696941000122-s2.0-003496222961830