Farshid, G.Downey, P.Gill, P.2008-04-142008-04-142007Breast, 2007; 16(2):161-1710960-97761532-3080http://hdl.handle.net/2440/42068Crown copyright © 2006 Published by Elsevier Ltd.Few series are published on DCIS that forms parenchymal lesions on screening mammograms. The implications of these unusual presentations for pre-operative assessment and surgical intervention are of interest. In the setting of a large, population-based breast cancer screening program, the diagnostic and management implications of DCIS presenting as parenchymal lesions on screening mammograms are investigated. A total of 125 lesions (20.1% of all DCIS) presented as a mass (n=99) or microcalcifications with an associated parenchymal lesion (n=26). Cytology was positive in 47.1% of cases. Core biopsy diagnosed DCIS in 68.4% of cases. Breast surgery after a definite preoperative diagnosis achieved negative initial margins in 69.4% case, versus 54.7% without a pre-operative malignant diagnosis. The mastectomy rate was 26.4%. Axillary surgery was carried out in 32.8% cases, including axillary clearance in 26.4% of cases. One in five cases of DCIS detected during mammographic screening has features other than pure microcalcifications. This has implications for pre-operative assessment and surgical management.enCarcinomaCytologyMammographyCore biopsyDCISBreast cancer screeningJournal article00200739762008041415441210.1016/j.breast.2006.08.0030002572738000102-s2.0-3404711169846668Farshid, G. [0000-0002-2056-0561]Gill, P. [0000-0001-7310-2970]