John, H.J.White, S.J.Byrapu, P.Raju, S.2025-05-302025-05-302025Cureus, 2025; 17(5):e84535-1-e84535-62168-81842168-8184https://hdl.handle.net/2440/144827Pulmonary tumour embolism is a rare complication of malignancy and should be considered a differential diagnosis if imaging features are atypical for a bland thrombus. It can arise from a range of primary tumours, including soft tissue sarcomas; however, reported cases are sparse. We present a case of pulmonary tumour embolism secondary to a large right knee myxofibrosarcoma, with diagnosis confirmed following biopsy of a pulmonary nodule and a palpable inguinal lymph nodeen© Copyright 2025 John et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedclinical case report; imaging findings; malignant myxofibrosarcoma; pulmonary embolism despite anticoagulation; pulmonary tumour embolismJournal article10.7759/cureus.84535740214White, S.J. [0000-0001-9374-3492]