Hu, C.Shi, J.Quan, S.Cui, B.Kleessen, S.Nikoloski, Z.Tohge, T.Alexander, D.Guo, L.Lin, H.Wang, J.Cui, X.Rao, J.Luo, Q.Zhao, X.Fernie, A.Zhang, D.2015-09-082015-09-082014Scientific Reports, 2014; 4(1):5067-1-5067-102045-23222045-2322http://hdl.handle.net/2440/94141Seed metabolites are critically important both for plant development and human nutrition; however, the natural variation in their levels remains poorly characterized. Here we profiled 121 metabolites in mature seeds of a wide panel Oryza sativa japonica and indica cultivars, revealing correlations between the metabolic phenotype and geographic origin of the rice seeds. Moreover, japonica and indica subspecies differed significantly not only in the relative abundances of metabolites but also in their corresponding metabolic association networks. These findings provide important insights into metabolic adaptation in rice subgroups, bridging the gap between genome and phenome, and facilitating the identification of genetic control of metabolic properties that can serve as a basis for the future improvement of rice quality via metabolic engineering.enThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/Metabolomics; Plant physiologyJournal article003002334810.1038/srep050672-s2.0-84901490737174059Zhang, D. [0000-0003-3181-9812]