A tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Wardhani, K.Levina, A.Sun, B.Grau, G.E.R.Keene, F.R.Collins, J.G.Lay, P.A.2023-06-072023-06-072023Chemical Communications, 2023; 59(45):6877-68801359-73451364-548Xhttps://hdl.handle.net/2440/138689A new photoluminescent polypyridylruthenium(II) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.enThis journal is © The Royal Society of Chemistry 2023Blood-Brain BarrierBrainEndotheliumEndothelial CellsHumansExtracellular VesiclesA tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endotheliumJournal article10.1039/d2cc05827h2023-06-06644522Keene, F.R. [0000-0001-7759-0465]