Yuvaraj,Thilagavathi,2025-12-172025-12-172017https://hdl.handle.net/11541.2/1309201 ethesis (xxiv, 147 pages) :colour illustrationsIncludes bibliographical references (pages 127-147)Lipoceramic (silica-lipid hybrid: SLH) microparticle formulations are solid oral dosage forms that demonstrate excellent drug delivery performance for a number of drugs with low water solubility and poor oral bioavailability (including celecoxib, ibuprofen, indomethacin and itraconazole). SLH is a novel lipid-based nanostructured delivery system identified as a potential strategy for peroral/oral administration of drugs. In this current research project the SLH system is extrapolated to enable oral delivery of the anti-cancer drug SN-38 (currently dosed intravenously) for potential oral chemotherapy. Patients’ prefer oral management in cancer chemotherapy due to its non-harmful procedure, the avoidance of frequent hospital visits and its potential to self-administer. Hence there is interest in the development of oral drug delivery system, which could overcome the current formulation and delivery challenges.enCancerDrug delivery systems.Pharmaceutical chemistry.Solid dosage forms.thesis