Ludbrook, G.Upton, R.Grant, C.Gray, E.2006-06-232006-06-231996Anaesthesia and Intensive Care, 1996; 24(4):445-4520310-057X1448-0271http://hdl.handle.net/2440/5919Publisher's copy made available with the permission of the publisher © 1996 Australian Society of AnaesthetistsThe time-course of propofol concentrations in the blood and brain following rapid administration of three doses were examined using a sheep preparation and regional pharmacokinetic techniques. These were compared to the time-course of cerebral effects of propofol reported previously. There were marked differences between the time-course of propofol concentrations in arterial blood and the brain, with a close relationship between the time-course of brain concentrations and effects on depth of anaesthesia and CBF. There was evidence that the effect of propofol on cerebral blood flow altered its own rate of elution from the brain. Hysteresis between arterial propofol concentrations and cerebral effects following rapid IV administration therefore appears to have a pharmacokinetic basis, and conventional compartmental pharmacokinetic analysis using blood concentrations alone may fail to accurately predict the time-course of both brain propofol concentrations and depth of anaesthesia.enanaesthesiacerebral blood flowpharmacologypropofolpharmacokineticsJournal article0030006108001996392610.1177/0310057x9602400406A1996VB379000062-s2.0-003020318570114Ludbrook, G. [0000-0001-6925-4277]Upton, R. [0000-0001-9996-4886]