Biros, E.Cooper, M.Palmer, L.Walker, P.Norman, P.Golledge, J.2014-06-182014-06-182010Atherosclerosis, 2010; 212(2):539-5420021-91501879-1484http://hdl.handle.net/2440/83493<h4>Objective</h4>Abdominal aortic aneurysm (AAA) has been recognized as a multi-factorial disease with both genetic and environmental risk factors. A locus residing within non-coding DNA on chromosome 9p21.3 has recently been associated with AAA. To further investigate the significance of this site for AAA, we performed an association study on a large group of 3371 men aged 65-83 years of whom 513 had an AAA.<h4>Methods</h4>All men were assessed for other risk factors in a uniform way and an ultrasound of the abdominal aorta was performed.<h4>Results</h4>Our findings validated the strong association of the chromosome 9p21.3 SNPs rs10757278 and rs1333049 with AAA and demonstrated the upregulation of LINE-1 elements at the site of AAA.<h4>Conclusion</h4>This study confirms a reproducible association between risk alleles on chromosome 9p21.3 and AAA. We also provide preliminary evidence for an association of LINE-1 elements with AAA which will require further investigation.enCopyright © 2010 Elsevier Ireland Ltd. All rights reserved.Abdominal aortic aneurysmRisk locusRetrotransposonsJournal article002013663410.1016/j.atherosclerosis.2010.06.0150002826785000302-s2.0-7795771637015521Palmer, L. [0000-0002-1628-3055]