Todd, G.Kimber, T.Ridding, M.Semmler, J.2010-04-142010-04-142010Clinical Neurophysiology, 2010; 121(3):441-4471388-24571872-8952http://hdl.handle.net/2440/57641<h4>Objective</h4>Ageing is accompanied by diminished practice-dependent plasticity. We investigated the effect of age on another plasticity inducing paradigm, repetitive transcranial magnetic stimulation (rTMS).<h4>Methods</h4>Healthy young (n=15; 25+/-4 years) and old (n=15; 67+/-5 years) adults participated in two experiments. Motor evoked potentials (MEPs) were measured in the target muscle (first dorsal interosseus, FDI) and a remote muscle (abductor digiti minimi) during a set of single stimuli. Subjects then received real or sham inhibitory rTMS (intermittent subthreshold trains of 6Hz stimulation for 10min). MEPs were measured for 30min after rTMS.<h4>Results</h4>In young adults, MEPs in the target FDI muscle were approximately 15% smaller in the real rTMS experiment than in the sham rTMS experiment (P<0.026). In old adults, FDI MEP size did not differ between experiments.<h4>Conclusions</h4>Advancing age is associated with reduced efficacy of inhibitory rTMS.<h4>Significance</h4>This work has important implications for the potential therapeutic use of rTMS in stroke and neurological disease.enCopyright 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reservedAgeRepetitive transcranial magnetic stimulationMotor cortexExcitabilityHumanJournal article002010007710.1016/j.clinph.2009.11.0890002745578000262-s2.0-7544910917433829Ridding, M. [0000-0001-5657-9136]Semmler, J. [0000-0003-0260-8047]