Avery, T.Caiazza, D.Culbert, J.Taylor, D.Tiekink, E.2007-02-252007-02-252005Journal of Organic Chemistry, 2005; 70(21):8344-83510022-32631520-6904http://hdl.handle.net/2440/17805Copyright © 2005 American Chemical SocietyA new method for the construction of tetrahydropyrans derived from readily available 1,2-dioxines containing a tethered hydroxyl moiety is described. The reaction proceeds via a base-catalyzed rearrangement of the 1,2-dioxines to either the isomeric cis or trans -hydroxy enones followed by intramolecular oxa-Michael addition of the tethered hydroxyl group.enHydroxyl RadicalHeterocyclic Compounds, 1-RingPyransAnticholesteremic AgentsMolecular StructureAntimitotic Agents1,2-dioxines containing tethered hydroxyl functionality as convenient precursors for pyran synthesesJournal article002005108910.1021/jo050806n0002324055000122-s2.0-2684443831854596Avery, T. [0000-0001-6882-5461]Taylor, D. [0000-0002-3302-4610] [0000-0002-4274-3983] [0000-0003-0633-7424]